Assay Detail
Functional
CHEMBL994179
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Cytotoxicity against camptothecin-resistant and TOP1 deficient mouse P388/CPT45 cells after MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | P388CPT45 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of N-substituted 5-[2-(N-alkylamino)ethyl]dibenzo[c,h][1,6]naphthyridines as novel topoisomerase I-targeting antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.58 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL484370 | — | — | 1 | 7.89 |
| CHEMBL484348 | — | — | 1 | 7.22 |
| CHEMBL520825 | — | — | 1 | 6.89 |
| CHEMBL485632 | — | — | 1 | 6.66 |
| CHEMBL70790 | — | — | 1 | 6.64 |
| CHEMBL485551 | — | — | 1 | 6.41 |
| CHEMBL521011 | — | — | 1 | 6.40 |
| CHEMBL485382 | — | — | 1 | 5.64 |
| CHEMBL485383 | — | — | 1 | 5.43 |
| CHEMBL483588 | — | — | 1 | - |
| CHEMBL483589 | — | — | 1 | - |
| CHEMBL521490 | — | — | 1 | - |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | - |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL484370 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL484348 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL520825 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL485632 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL70790 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL485551 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL521011 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL485382 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL485383 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL483588 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL483589 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL521490 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL65 | CAMPTOTHECIN | IC50 | > | 10000.0 | nM | - |
| CHEMBL84 | TOPOTECAN | IC50 | > | 10000.0 | nM | - |