Assay Detail
Functional
CHEMBL994180
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Cytotoxicity against human KB3-1 cells after MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB 3-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of N-substituted 5-[2-(N-alkylamino)ethyl]dibenzo[c,h][1,6]naphthyridines as novel topoisomerase I-targeting antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.40 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL520825 | — | — | 1 | 8.40 |
| CHEMBL70790 | — | — | 1 | 8.30 |
| CHEMBL485632 | — | — | 1 | 8.30 |
| CHEMBL484348 | — | — | 1 | 8.22 |
| CHEMBL485551 | — | — | 1 | 8.00 |
| CHEMBL521011 | — | — | 1 | 7.70 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 7.40 |
| CHEMBL485382 | — | — | 1 | 7.16 |
| CHEMBL484370 | — | — | 1 | 7.16 |
| CHEMBL485383 | — | — | 1 | 7.00 |
| CHEMBL483588 | — | — | 1 | 6.39 |
| CHEMBL483589 | — | — | 1 | 6.19 |
| CHEMBL521490 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL520825 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL70790 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL485632 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL484348 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL485551 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL521011 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL485382 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL484370 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL485383 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL483588 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL483589 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL521490 | — | IC50 | = | 1000.0 | nM | 6.00 |