Assay Detail
Functional
CHEMBL994182
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against multidrug resistant human KBH5.0 cells overexpressing BCRP after MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KBH5.0 cell |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of N-substituted 5-[2-(N-alkylamino)ethyl]dibenzo[c,h][1,6]naphthyridines as novel topoisomerase I-targeting antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.06 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70790 | — | — | 1 | 8.22 |
| CHEMBL520825 | — | — | 1 | 8.15 |
| CHEMBL484348 | — | — | 1 | 8.05 |
| CHEMBL485632 | — | — | 1 | 7.57 |
| CHEMBL521011 | — | — | 1 | 7.47 |
| CHEMBL485383 | — | — | 1 | 7.16 |
| CHEMBL484370 | — | — | 1 | 7.00 |
| CHEMBL485382 | — | — | 1 | 6.96 |
| CHEMBL485551 | — | — | 1 | 6.50 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 6.36 |
| CHEMBL483588 | — | — | 1 | 6.20 |
| CHEMBL483589 | — | — | 1 | 6.12 |
| CHEMBL521490 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70790 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL520825 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL484348 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL485632 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL521011 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL485383 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL484370 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL485382 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL485551 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL483588 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL483589 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL521490 | — | IC50 | = | 1100.0 | nM | 5.96 |