Assay Detail
Functional
CHEMBL994472
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Antiviral activity against HIV1 3B in human MT4 cells assessed as virus-induced cytopathogenicity after 5 days
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Novel N1-substituted 1,3-dihydro-2H-benzimidazol-2-ones as potent non-nucleoside reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 26 | 6.71 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 9.05 |
| CHEMBL234401 | — | — | 1 | 8.70 |
| CHEMBL443883 | — | — | 1 | 8.20 |
| CHEMBL479068 | — | — | 1 | 7.93 |
| CHEMBL234400 | — | — | 1 | 7.50 |
| CHEMBL478236 | — | — | 1 | 7.19 |
| CHEMBL518737 | — | — | 1 | 7.16 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 7.14 |
| CHEMBL477603 | — | — | 1 | 7.12 |
| CHEMBL506852 | — | — | 1 | 7.12 |
| CHEMBL447646 | — | — | 1 | 6.71 |
| CHEMBL393003 | — | — | 1 | 6.62 |
| CHEMBL479069 | — | — | 1 | 6.54 |
| CHEMBL443879 | — | — | 1 | 6.37 |
| CHEMBL514396 | — | — | 1 | 6.35 |
| CHEMBL514527 | — | — | 1 | 6.27 |
| CHEMBL502115 | — | — | 1 | 6.13 |
| CHEMBL516423 | — | — | 1 | 6.03 |
| CHEMBL507975 | — | — | 1 | 5.80 |
| CHEMBL477602 | — | — | 1 | 5.78 |
| CHEMBL450764 | — | — | 1 | 5.26 |
| CHEMBL518738 | — | — | 1 | 4.73 |
| CHEMBL515189 | — | — | 1 | 4.54 |
| CHEMBL444417 | — | — | 1 | - |
| CHEMBL478235 | — | — | 1 | - |
| CHEMBL477192 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL234401 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL443883 | — | EC50 | = | 6.3 | nM | 8.20 |
| CHEMBL479068 | — | EC50 | = | 11.7 | nM | 7.93 |
| CHEMBL234400 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL478236 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL518737 | — | EC50 | = | 69.0 | nM | 7.16 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 73.0 | nM | 7.14 |
| CHEMBL477603 | — | EC50 | = | 75.0 | nM | 7.12 |
| CHEMBL506852 | — | EC50 | = | 76.0 | nM | 7.12 |
| CHEMBL447646 | — | EC50 | = | 195.0 | nM | 6.71 |
| CHEMBL393003 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL479069 | — | EC50 | = | 289.0 | nM | 6.54 |
| CHEMBL443879 | — | EC50 | = | 425.0 | nM | 6.37 |
| CHEMBL514396 | — | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL514527 | — | EC50 | = | 534.0 | nM | 6.27 |
| CHEMBL502115 | — | EC50 | = | 740.0 | nM | 6.13 |
| CHEMBL516423 | — | EC50 | = | 938.0 | nM | 6.03 |
| CHEMBL507975 | — | EC50 | = | 1566.0 | nM | 5.80 |
| CHEMBL477602 | — | EC50 | = | 1663.0 | nM | 5.78 |
| CHEMBL450764 | — | EC50 | = | 5497.0 | nM | 5.26 |
| CHEMBL518738 | — | EC50 | = | 18560.0 | nM | 4.73 |
| CHEMBL515189 | — | EC50 | = | 28975.0 | nM | 4.54 |
| CHEMBL444417 | — | EC50 | > | 737.0 | nM | - |
| CHEMBL478235 | — | EC50 | > | 72950.0 | nM | - |
| CHEMBL477192 | — | EC50 | > | 33900.0 | nM | - |