Assay Detail
Binding
CHEMBL994692
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Displacement of [3H]LSD from human recombinant 5HT6 receptor
54
Total Activities
54
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and SAR of tolylamine 5-HT6 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 54 | 7.84 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL483358 | — | — | 1 | 9.22 |
| CHEMBL431298 | — | — | 1 | 9.18 |
| CHEMBL483148 | — | — | 1 | 8.89 |
| CHEMBL520638 | — | — | 1 | 8.82 |
| CHEMBL482989 | — | — | 1 | 8.62 |
| CHEMBL450673 | — | — | 1 | 8.60 |
| CHEMBL527098 | — | — | 1 | 8.57 |
| CHEMBL484164 | — | — | 1 | 8.55 |
| CHEMBL485147 | — | — | 1 | 8.48 |
| CHEMBL482937 | — | — | 1 | 8.46 |
| CHEMBL482990 | — | — | 1 | 8.37 |
| CHEMBL482737 | — | — | 1 | 8.24 |
| CHEMBL482938 | — | — | 1 | 8.19 |
| CHEMBL482988 | — | — | 1 | 8.19 |
| CHEMBL506736 | — | — | 1 | 8.16 |
| CHEMBL484009 | — | — | 1 | 8.09 |
| CHEMBL483560 | — | — | 1 | 8.03 |
| CHEMBL484533 | — | — | 1 | 8.00 |
| CHEMBL483149 | — | — | 1 | 7.99 |
| CHEMBL484337 | — | — | 1 | 7.98 |
| CHEMBL482749 | — | — | 1 | 7.95 |
| CHEMBL483559 | — | — | 1 | 7.94 |
| CHEMBL519513 | — | — | 1 | 7.87 |
| CHEMBL484534 | — | — | 1 | 7.82 |
| CHEMBL483558 | — | — | 1 | 7.82 |
| CHEMBL519536 | — | — | 1 | 7.75 |
| CHEMBL519670 | — | — | 1 | 7.75 |
| CHEMBL482541 | — | — | 1 | 7.74 |
| CHEMBL484010 | — | — | 1 | 7.72 |
| CHEMBL482939 | — | — | 1 | 7.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL483358 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL431298 | — | Ki | = | 0.66 | nM | 9.18 |
| CHEMBL483148 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL520638 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL482989 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL450673 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL527098 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL484164 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL485147 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL482937 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL482990 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL482737 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL482938 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL482988 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL506736 | — | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL484009 | — | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL483560 | — | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL484533 | — | Ki | = | 10.1 | nM | 8.00 |
| CHEMBL483149 | — | Ki | = | 10.3 | nM | 7.99 |
| CHEMBL484337 | — | Ki | = | 10.5 | nM | 7.98 |
| CHEMBL482749 | — | Ki | = | 11.3 | nM | 7.95 |
| CHEMBL483559 | — | Ki | = | 11.6 | nM | 7.94 |
| CHEMBL519513 | — | Ki | = | 13.6 | nM | 7.87 |
| CHEMBL484534 | — | Ki | = | 15.1 | nM | 7.82 |
| CHEMBL483558 | — | Ki | = | 15.3 | nM | 7.82 |
| CHEMBL519536 | — | Ki | = | 17.9 | nM | 7.75 |
| CHEMBL519670 | — | Ki | = | 17.8 | nM | 7.75 |
| CHEMBL482541 | — | Ki | = | 18.4 | nM | 7.74 |
| CHEMBL484010 | — | Ki | = | 19.1 | nM | 7.72 |
| CHEMBL482939 | — | Ki | = | 19.6 | nM | 7.71 |
| CHEMBL484532 | — | Ki | = | 24.7 | nM | 7.61 |
| CHEMBL453732 | — | Ki | = | 26.1 | nM | 7.58 |
| CHEMBL482748 | — | Ki | = | 28.9 | nM | 7.54 |
| CHEMBL485531 | — | Ki | = | 39.5 | nM | 7.40 |
| CHEMBL485010 | — | Ki | = | 39.8 | nM | 7.40 |
| CHEMBL455332 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL484964 | — | Ki | = | 45.6 | nM | 7.34 |
| CHEMBL474089 | — | Ki | = | 48.5 | nM | 7.31 |
| CHEMBL475902 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL482568 | — | Ki | = | 61.6 | nM | 7.21 |
| CHEMBL484965 | — | Ki | = | 70.7 | nM | 7.15 |
| CHEMBL484608 | — | Ki | = | 92.5 | nM | 7.03 |
| CHEMBL482573 | — | Ki | = | 126.0 | nM | 6.90 |
| CHEMBL452402 | — | Ki | = | 174.0 | nM | 6.76 |
| CHEMBL485016 | — | Ki | = | 208.0 | nM | 6.68 |
| CHEMBL519359 | — | Ki | = | 219.0 | nM | 6.66 |
| CHEMBL474088 | — | Ki | = | 239.0 | nM | 6.62 |
| CHEMBL449581 | — | Ki | > | 440.0 | nM | - |
| CHEMBL484008 | — | Ki | > | 440.0 | nM | - |
| CHEMBL475901 | — | Ki | > | 440.0 | nM | - |