Assay Detail

CHEMBL994714

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Binding

Binding affinity to human NK3 receptor

ChEMBL ↗

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Target

Neuromedin-K receptor (CHEMBL4429) ↗

Open DB target context

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Neuromedin-K receptor (CHEMBL4429) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Neuromedin-K receptor

CHEMBL4429

Anchored from Assay target.

Protein identity Neuromedin-K receptor

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Neuromedin-K receptor (CHEMBL4429) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Potent, brain-penetrant, hydroisoindoline-based human neurokinin-1 receptor antagonists.

Jiang J, Bunda JL, Doss GA, Chicchi GG, Kurtz MM, Tsao KL, Tong X, Zheng S, Upthagrove A, Samuel K, Tschirret-Guth R, Kumar S, Wheeldon A, Carlson EJ, Hargreaves R, Burns D, Hamill T, Ryan C, Krause SM, Eng W, DeVita RJ, Mills SG.
J Med Chem (2009) 52 : 3039 -3046
PubMed 19354254 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	8.62	8.62

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL447955	SERLOPITANT	3.0	1	8.62

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL447955	SERLOPITANT	Ki	=	2.4	nM	8.62