Assay Detail
Functional
CHEMBL995035
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Induction of apoptosis in human HCT 116 cells assessed as caspase 3 activation by HTS assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 4-aryl-2-oxo-2H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 7.26 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL399124 | — | — | 1 | 8.52 |
| CHEMBL196832 | — | — | 1 | 8.05 |
| CHEMBL515623 | — | — | 1 | 8.00 |
| CHEMBL477815 | — | — | 1 | 7.89 |
| CHEMBL477186 | — | — | 1 | 7.85 |
| CHEMBL476982 | — | — | 1 | 7.80 |
| CHEMBL477383 | — | — | 1 | 7.75 |
| CHEMBL445486 | — | — | 1 | 7.70 |
| CHEMBL477814 | — | — | 1 | 7.70 |
| CHEMBL476761 | — | — | 1 | 7.57 |
| CHEMBL515320 | — | — | 1 | 7.39 |
| CHEMBL477384 | — | — | 1 | 7.23 |
| CHEMBL477189 | — | — | 1 | 6.40 |
| CHEMBL477188 | — | — | 1 | 6.00 |
| CHEMBL477395 | — | — | 1 | 5.32 |
| CHEMBL477394 | — | — | 1 | 5.03 |
| CHEMBL373137 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL399124 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL196832 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL515623 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL477815 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL477186 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL476982 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL477383 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL445486 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL477814 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL476761 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL515320 | — | EC50 | = | 41.0 | nM | 7.39 |
| CHEMBL477384 | — | EC50 | = | 59.0 | nM | 7.23 |
| CHEMBL477189 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL477188 | — | EC50 | = | 990.0 | nM | 6.00 |
| CHEMBL477395 | — | EC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL477394 | — | EC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL373137 | — | EC50 | - | — | - |