Assay Detail
Functional
CHEMBL995036
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Induction of apoptosis in human SNU398 cells assessed as caspase 3 activation by HTS assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SNU-398 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 4-aryl-2-oxo-2H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 7.42 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL399124 | — | — | 1 | 8.70 |
| CHEMBL515623 | — | — | 1 | 8.22 |
| CHEMBL477186 | — | — | 1 | 8.02 |
| CHEMBL477815 | — | — | 1 | 8.02 |
| CHEMBL445486 | — | — | 1 | 7.89 |
| CHEMBL476982 | — | — | 1 | 7.85 |
| CHEMBL477383 | — | — | 1 | 7.82 |
| CHEMBL476761 | — | — | 1 | 7.77 |
| CHEMBL477814 | — | — | 1 | 7.77 |
| CHEMBL196832 | — | — | 1 | 7.72 |
| CHEMBL515320 | — | — | 1 | 7.58 |
| CHEMBL477384 | — | — | 1 | 7.54 |
| CHEMBL477189 | — | — | 1 | 6.58 |
| CHEMBL477188 | — | — | 1 | 6.31 |
| CHEMBL477395 | — | — | 1 | 5.60 |
| CHEMBL477394 | — | — | 1 | 5.26 |
| CHEMBL373137 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL399124 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL515623 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL477186 | — | EC50 | = | 9.6 | nM | 8.02 |
| CHEMBL477815 | — | EC50 | = | 9.5 | nM | 8.02 |
| CHEMBL445486 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL476982 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL477383 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL476761 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL477814 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL196832 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL515320 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL477384 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL477189 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL477188 | — | EC50 | = | 490.0 | nM | 6.31 |
| CHEMBL477395 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL477394 | — | EC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL373137 | — | EC50 | - | — | - |