Assay Detail
Binding
CHEMBL995059
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Inhibition of MEK1 by raf/MEK1/MAPK coupled assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Dual specificity mitogen-activated protein kinase kinase 1 (CHEMBL3587) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
4-Anilino-7-alkenylquinoline-3-carbonitriles as potent MEK1 kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.80 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL103045 | — | — | 1 | 8.52 |
| CHEMBL485615 | — | — | 1 | 8.52 |
| CHEMBL524111 | — | — | 1 | 8.40 |
| CHEMBL520025 | — | — | 1 | 8.30 |
| CHEMBL450271 | — | — | 1 | 8.22 |
| CHEMBL485238 | — | — | 1 | 8.00 |
| CHEMBL485237 | — | — | 1 | 7.96 |
| CHEMBL489058 | — | — | 1 | 7.92 |
| CHEMBL520142 | — | — | 1 | 7.72 |
| CHEMBL521502 | — | — | 1 | 7.70 |
| CHEMBL485574 | — | — | 1 | 7.68 |
| CHEMBL483398 | — | — | 1 | 7.60 |
| CHEMBL484368 | — | — | 1 | 7.58 |
| CHEMBL489661 | — | — | 1 | 7.48 |
| CHEMBL519206 | — | — | 1 | 7.46 |
| CHEMBL485377 | — | — | 1 | 7.44 |
| CHEMBL521320 | — | — | 1 | 7.28 |
| CHEMBL485211 | — | — | 1 | 7.26 |
| CHEMBL521013 | — | — | 1 | 7.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL103045 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL485615 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL524111 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL520025 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL450271 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL485238 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL485237 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL489058 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL520142 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL521502 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL485574 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL483398 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL484368 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL489661 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL519206 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL485377 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL521320 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL485211 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL521013 | — | IC50 | = | 59.0 | nM | 7.23 |