Assay Detail
Binding
CHEMBL995089
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Displacement of [3H]spiperone from human D3 receptor expressed in CHO cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel D3 selective dopaminergics incorporating enyne units as nonaromatic catechol bioisosteres: synthesis, bioactivity, and mutagenesis studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.41 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58669 | — | — | 1 | 9.70 |
| CHEMBL484358 | — | — | 1 | 9.68 |
| CHEMBL484202 | — | — | 1 | 8.89 |
| CHEMBL483593 | — | — | 1 | 8.36 |
| CHEMBL485384 | — | — | 1 | 7.89 |
| CHEMBL485227 | — | — | 1 | 6.85 |
| CHEMBL491466 | — | — | 1 | 6.82 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 6.62 |
| CHEMBL484203 | — | — | 1 | 6.55 |
| CHEMBL484357 | — | — | 1 | 6.52 |
| CHEMBL484204 | — | — | 1 | 6.02 |
| CHEMBL444128 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58669 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL484358 | — | Ki | = | 0.21 | nM | 9.68 |
| CHEMBL484202 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL483593 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL485384 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL485227 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL491466 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL59 | DOPAMINE | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL484203 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL484357 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL484204 | — | Ki | = | 950.0 | nM | 6.02 |
| CHEMBL444128 | — | Ki | = | 11000.0 | nM | 4.96 |