Compound Detail
CHEMBL58669
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Basic Information
| ChEMBL ID | CHEMBL58669 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RISZOHTXHUANFZ-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
456.6
MW (Da)
5.84
ALogP
3
HBA
2
HBD
52.6
PSA (Ų)
0.38
QED
1
Ro5 Violations
10
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 9.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| D(3) dopamine receptor CHEMBL234 | Ki | 9.7 | 9.7 | 0.2 | 2 |
| D(2) dopamine receptor CHEMBL217 | Ki | 7.6 | 7.6 | 25.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| D(3) dopamine receptor | Ki | = | 0.1995 | nM | 9.7 | Displacement of [125I]iodosulpiride from human Dopamine receptor D3 expressed in... | - |
| D(3) dopamine receptor | Ki | = | 0.2 | nM | 9.7 | Displacement of [3H]spiperone from human D3 receptor expressed in CHO cells | 18834111 |
| D(2) dopamine receptor | Ki | = | 25.12 | nM | 7.6 | Displacement of [125I]iodosulpiride from human Dopamine receptor D2 expressed in... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(97)00350-8 | D(3) dopamine receptor | 2 |
| - | 10.1016/S0960-894X(97)00350-8 | D(2) dopamine receptor | 1 |
| 18834111 | 10.1021/jm800895v | D(3) dopamine receptor | 1 |
Data from ChEMBL 36 via Core Engine