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Assay Detail

CHEMBL995172

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of factor 10a in human plasma
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Tissue Plasma
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Coagulation factor X (CHEMBL244)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Orally active factor Xa inhibitors: investigation of a novel series of 3-amidinophenylsulfonamide derivatives using an amidoxime prodrug strategy.
Uchida M, Okazaki K, Mukaiyama H, Isawa H, Kobayashi H, Shiohara H, Muranaka H, Kai Y, Kikuchi N, Takeuchi H, Yokoyama K, Tsuji E, Ozawa T, Hoyano Y, Koizumi T, Misawa K, Hara K, Nakano S, Murakami Y, Okuno H.
Bioorg Med Chem Lett (2008) 18 : 4682 -4687
PubMed 18667303 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 7.39 7.39

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL19902 DX-9065A 1 7.39

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL19902 DX-9065A Ki = 41.0 nM 7.39