Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL995175

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human factor 10a by Dixon-plot method
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Coagulation factor X (CHEMBL244)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Orally active factor Xa inhibitors: investigation of a novel series of 3-amidinophenylsulfonamide derivatives using an amidoxime prodrug strategy.
Uchida M, Okazaki K, Mukaiyama H, Isawa H, Kobayashi H, Shiohara H, Muranaka H, Kai Y, Kikuchi N, Takeuchi H, Yokoyama K, Tsuji E, Ozawa T, Hoyano Y, Koizumi T, Misawa K, Hara K, Nakano S, Murakami Y, Okuno H.
Bioorg Med Chem Lett (2008) 18 : 4682 -4687
PubMed 18667303 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 20 6.77 8.76

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL463385 1 8.76
CHEMBL455932 1 8.30
CHEMBL455933 1 8.24
CHEMBL459136 1 8.01
CHEMBL455916 1 7.85
CHEMBL456763 1 7.57
CHEMBL463581 1 7.54
CHEMBL458067 1 7.29
CHEMBL455914 1 7.23
CHEMBL457633 1 7.21
CHEMBL513605 1 7.00
CHEMBL463179 1 6.30
CHEMBL513433 1 5.68
CHEMBL457391 1 5.52
CHEMBL457632 1 5.46
CHEMBL455919 1 5.43
CHEMBL509493 1 5.16
CHEMBL455915 1 5.14
CHEMBL457392 1 4.85
CHEMBL458068 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL463385 Ki = 1.73 nM 8.76
CHEMBL455932 Ki = 5.0 nM 8.30
CHEMBL455933 Ki = 5.7 nM 8.24
CHEMBL459136 Ki = 9.7 nM 8.01
CHEMBL455916 Ki = 14.0 nM 7.85
CHEMBL456763 Ki = 27.0 nM 7.57
CHEMBL463581 Ki = 29.0 nM 7.54
CHEMBL458067 Ki = 51.0 nM 7.29
CHEMBL455914 Ki = 59.0 nM 7.23
CHEMBL457633 Ki = 62.0 nM 7.21
CHEMBL513605 Ki = 100.0 nM 7.00
CHEMBL463179 Ki = 500.0 nM 6.30
CHEMBL513433 Ki = 2100.0 nM 5.68
CHEMBL457391 Ki = 3000.0 nM 5.52
CHEMBL457632 Ki = 3500.0 nM 5.46
CHEMBL455919 Ki = 3700.0 nM 5.43
CHEMBL509493 Ki = 7000.0 nM 5.16
CHEMBL455915 Ki = 7300.0 nM 5.14
CHEMBL457392 Ki = 14000.0 nM 4.85
CHEMBL458068 Ki > 10000.0 nM -