Assay Detail
Functional
CHEMBL995327
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Antioxidant activity assessed as inhibition of endothelial cell-induced human LDL oxidation
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | Endothelial cell |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of 3',5'-di-tert-butyl-4'-hydroxyflavones as potential inhibitors of low density lipoprotein (LDL) oxidation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.54 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL488415 | — | — | 1 | 6.30 |
| CHEMBL507729 | — | — | 1 | 6.30 |
| CHEMBL521061 | — | — | 1 | 6.10 |
| CHEMBL529212 | — | — | 1 | 6.10 |
| CHEMBL90286 | — | — | 1 | 5.70 |
| CHEMBL486213 | — | — | 1 | 5.60 |
| CHEMBL608 | PROBUCOL | 4.0 | 1 | 5.40 |
| CHEMBL3989727 | VITAMIN E | 4.0 | 1 | 5.40 |
| CHEMBL488416 | — | — | 1 | 4.30 |
| CHEMBL500296 | — | — | 1 | 4.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL488415 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL507729 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL521061 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL529212 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL90286 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL486213 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL608 | PROBUCOL | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3989727 | VITAMIN E | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL488416 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL500296 | — | IC50 | = | 70000.0 | nM | 4.16 |