Assay Detail
Binding
CHEMBL995584
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Inhibition of human 11beta HSD1 by SPA assay
52
Total Activities
52
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
11-beta-hydroxysteroid dehydrogenase 1 (CHEMBL4235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
4-Methyl-5-phenyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 52 | 8.50 | 9.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL497748 | — | — | 1 | 9.55 |
| CHEMBL494180 | — | — | 1 | 9.47 |
| CHEMBL495889 | — | — | 1 | 9.01 |
| CHEMBL521536 | — | — | 1 | 9.01 |
| CHEMBL496307 | — | — | 1 | 9.01 |
| CHEMBL496714 | — | — | 1 | 9.01 |
| CHEMBL497951 | — | — | 1 | 9.00 |
| CHEMBL523414 | — | — | 1 | 9.00 |
| CHEMBL497121 | — | — | 1 | 9.00 |
| CHEMBL522066 | — | — | 1 | 9.00 |
| CHEMBL522701 | — | — | 1 | 9.00 |
| CHEMBL494638 | — | — | 1 | 9.00 |
| CHEMBL496095 | — | — | 1 | 9.00 |
| CHEMBL521688 | — | — | 1 | 9.00 |
| CHEMBL257149 | — | — | 1 | 8.89 |
| CHEMBL508147 | — | — | 1 | 8.82 |
| CHEMBL523177 | — | — | 1 | 8.77 |
| CHEMBL497122 | — | — | 1 | 8.77 |
| CHEMBL494206 | — | — | 1 | 8.74 |
| CHEMBL524824 | — | — | 1 | 8.70 |
| CHEMBL496096 | — | — | 1 | 8.70 |
| CHEMBL496294 | — | — | 1 | 8.70 |
| CHEMBL497555 | — | — | 1 | 8.68 |
| CHEMBL496295 | — | — | 1 | 8.66 |
| CHEMBL525606 | — | — | 1 | 8.66 |
| CHEMBL494809 | — | — | 1 | 8.64 |
| CHEMBL525360 | — | — | 1 | 8.59 |
| CHEMBL494819 | — | — | 1 | 8.57 |
| CHEMBL525003 | — | — | 1 | 8.57 |
| CHEMBL524040 | — | — | 1 | 8.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL497748 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL494180 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL521536 | — | IC50 | = | 0.98 | nM | 9.01 |
| CHEMBL496307 | — | IC50 | = | 0.98 | nM | 9.01 |
| CHEMBL496714 | — | IC50 | = | 0.98 | nM | 9.01 |
| CHEMBL495889 | — | IC50 | = | 0.98 | nM | 9.01 |
| CHEMBL497951 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL523414 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL497121 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL522066 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL522701 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL494638 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL496095 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL521688 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL257149 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL508147 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL523177 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL497122 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL494206 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL524824 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL496096 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL496294 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL497555 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL496295 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL525606 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL494809 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL525360 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL494819 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL525003 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL524040 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL496097 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL494637 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL498351 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL524623 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL525924 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL498352 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL498153 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL256777 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL498353 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL522572 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL497960 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL525361 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL495690 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL496495 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL494822 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL522533 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL497554 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL497558 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL493801 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL428429 | FIG 1 | IC50 | = | 37.0 | nM | 7.43 |