Compound Detail
CHEMBL496714
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Basic Information
| ChEMBL ID | CHEMBL496714 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IUBGICNCLXPBGO-UHFFFAOYSA-N |
3
Targets
3
Activities
2
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
492.3
MW (Da)
6.46
ALogP
5
HBA
0
HBD
48.5
PSA (Ų)
0.33
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 9.02
EC50 1 meas. best 5.5
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 11-beta-hydroxysteroid dehydrogenase 1 CHEMBL3910 | IC50 | 9.02 | 9.02 | 1.0 | 1 |
| 11-beta-hydroxysteroid dehydrogenase 1 CHEMBL4235 | IC50 | 9.01 | 9.01 | 1.0 | 1 |
| Nuclear receptor subfamily 1 group I member 2 CHEMBL3401 | EC50 | 5.5 | 5.5 | 3200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 11-beta-hydroxysteroid dehydrogenase 1 | IC50 | = | 0.96 | nM | 9.02 | Inhibition of mouse 11beta HSD1 by SPA assay | 18440811 |
| 11-beta-hydroxysteroid dehydrogenase 1 | IC50 | = | 0.98 | nM | 9.01 | Inhibition of human 11beta HSD1 by SPA assay | 18440811 |
| Nuclear receptor subfamily 1 group I member 2 | EC50 | = | 3200.0 | nM | 5.5 | Agonist activity at human PXR | 18440811 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18440811 | 10.1016/j.bmcl.2008.04.013 | 11-beta-hydroxysteroid dehydrogenase 1 | 2 |
| 18440811 | 10.1016/j.bmcl.2008.04.013 | Mus musculus | 2 |
| 18440811 | 10.1016/j.bmcl.2008.04.013 | Nuclear receptor subfamily 1 group I member 2 | 2 |
| 18440811 | 10.1016/j.bmcl.2008.04.013 | 11-beta-hydroxysteroid dehydrogenase type 2 | 1 |
Data from ChEMBL 36 via Core Engine