Assay Detail
Binding
CHEMBL995846
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Inhibition of EGFR kinase
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Dual EGFR/ErbB-2 inhibitors from novel pyrrolidinyl-acetylenic thieno[3,2-d]pyrimidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.24 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL496174 | — | — | 1 | 8.15 |
| CHEMBL497804 | — | — | 1 | 7.85 |
| CHEMBL517123 | GSK-182497A | — | 1 | 7.55 |
| CHEMBL512076 | GSK-192082A | — | 1 | 7.50 |
| CHEMBL501705 | — | — | 1 | 7.30 |
| CHEMBL466586 | — | — | 1 | 7.30 |
| CHEMBL495734 | — | — | 1 | 7.24 |
| CHEMBL525805 | — | — | 1 | 7.22 |
| CHEMBL500381 | — | — | 1 | 7.20 |
| CHEMBL507329 | GW869810X | — | 1 | 7.19 |
| CHEMBL500115 | — | — | 1 | 7.09 |
| CHEMBL495979 | — | — | 1 | 6.96 |
| CHEMBL497184 | — | — | 1 | 6.94 |
| CHEMBL495733 | — | — | 1 | 6.92 |
| CHEMBL523573 | — | — | 1 | 6.89 |
| CHEMBL497803 | — | — | 1 | 6.85 |
| CHEMBL500640 | — | — | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL496174 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL497804 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL517123 | GSK-182497A | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL512076 | GSK-192082A | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL501705 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL466586 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL495734 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL525805 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL500381 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL507329 | GW869810X | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL500115 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL495979 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL497184 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL495733 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL523573 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL497803 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL500640 | — | IC50 | = | 141.0 | nM | 6.85 |