Assay Detail
Binding
CHEMBL995859
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Inhibition of mouse macrophage COX2
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
QSAR analysis of 1,3-diaryl-4,5,6,7-tetrahydro-2H-isoindole derivatives as selective COX-2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 7.87 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL140167 | — | — | 1 | 9.22 |
| CHEMBL142650 | — | — | 1 | 9.15 |
| CHEMBL143776 | — | — | 1 | 8.96 |
| CHEMBL344085 | — | — | 1 | 8.82 |
| CHEMBL343701 | — | — | 1 | 8.80 |
| CHEMBL441663 | — | — | 1 | 8.77 |
| CHEMBL335371 | — | — | 1 | 8.74 |
| CHEMBL341878 | — | — | 1 | 8.59 |
| CHEMBL142038 | — | — | 1 | 8.54 |
| CHEMBL343339 | — | — | 1 | 8.51 |
| CHEMBL140804 | — | — | 1 | 8.48 |
| CHEMBL139721 | — | — | 1 | 8.35 |
| CHEMBL140726 | — | — | 1 | 8.30 |
| CHEMBL343311 | — | — | 1 | 7.84 |
| CHEMBL140991 | — | — | 1 | 7.78 |
| CHEMBL140876 | — | — | 1 | 7.67 |
| CHEMBL140533 | — | — | 1 | 7.45 |
| CHEMBL139591 | — | — | 1 | 7.38 |
| CHEMBL141312 | — | — | 1 | 6.30 |
| CHEMBL140171 | — | — | 1 | 6.30 |
| CHEMBL344841 | — | — | 1 | 6.15 |
| CHEMBL345038 | — | — | 1 | 6.00 |
| CHEMBL344381 | — | — | 1 | 5.00 |
| CHEMBL522912 | — | — | 1 | - |
| CHEMBL140206 | — | — | 1 | - |
| CHEMBL496776 | — | — | 1 | - |
| CHEMBL343716 | — | — | 1 | - |
| CHEMBL445127 | — | — | 1 | - |
| CHEMBL337601 | — | — | 1 | - |
| CHEMBL496775 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL140167 | — | IC50 | = | 0.6012 | nM | 9.22 |
| CHEMBL142650 | — | IC50 | = | 0.7015 | nM | 9.15 |
| CHEMBL143776 | — | IC50 | = | 1.102 | nM | 8.96 |
| CHEMBL344085 | — | IC50 | = | 1.503 | nM | 8.82 |
| CHEMBL343701 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL441663 | — | IC50 | = | 1.702 | nM | 8.77 |
| CHEMBL335371 | — | IC50 | = | 1.803 | nM | 8.74 |
| CHEMBL341878 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL142038 | — | IC50 | = | 2.904 | nM | 8.54 |
| CHEMBL343339 | — | IC50 | = | 3.105 | nM | 8.51 |
| CHEMBL140804 | — | IC50 | = | 3.304 | nM | 8.48 |
| CHEMBL139721 | — | IC50 | = | 4.508 | nM | 8.35 |
| CHEMBL140726 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL343311 | — | IC50 | = | 14.52 | nM | 7.84 |
| CHEMBL140991 | — | IC50 | = | 16.71 | nM | 7.78 |
| CHEMBL140876 | — | IC50 | = | 21.33 | nM | 7.67 |
| CHEMBL140533 | — | IC50 | = | 35.65 | nM | 7.45 |
| CHEMBL139591 | — | IC50 | = | 42.07 | nM | 7.38 |
| CHEMBL141312 | — | IC50 | = | 500.03 | nM | 6.30 |
| CHEMBL140171 | — | IC50 | = | 500.03 | nM | 6.30 |
| CHEMBL344841 | — | IC50 | = | 701.46 | nM | 6.15 |
| CHEMBL345038 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL344381 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL522912 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL140206 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL496776 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL343716 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL445127 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL337601 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL496775 | — | IC50 | > | 100.0 | nM | - |