Assay Detail
Binding
CHEMBL995863
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Displacement of [3H]CCPA from adenosine A1 receptor in Wistar rat cerebral cortex by liquid scintillation counting
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
N6-1,3-diphenylurea derivatives of 2-phenyl-9-benzyladenines and 8-azaadenines: synthesis and biological evaluation as allosteric modulators of A2A adenosine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.59 | 6.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL492052 | — | — | 1 | 6.99 |
| CHEMBL496985 | — | — | 1 | 6.53 |
| CHEMBL496984 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL492052 | — | Ki | = | 103.0 | nM | 6.99 |
| CHEMBL496985 | — | Ki | = | 294.0 | nM | 6.53 |
| CHEMBL496984 | — | Ki | = | 571.0 | nM | 6.24 |