Assay Detail
Binding
CHEMBL995865
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Displacement of [3H]ZM241385 from human recombinant adenosine A2A receptor expressed in CHO cells by liquid scintillation counting
5
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
N6-1,3-diphenylurea derivatives of 2-phenyl-9-benzyladenines and 8-azaadenines: synthesis and biological evaluation as allosteric modulators of A2A adenosine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.62 | 5.89 |
| EC50 | 2 | 4.91 | 5.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL492052 | — | — | 2 | 5.89 |
| CHEMBL496984 | — | — | 1 | 5.72 |
| CHEMBL496985 | — | — | 1 | 5.24 |
| CHEMBL487497 | — | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL492052 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL496984 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL496985 | — | Ki | = | 5737.0 | nM | 5.24 |
| CHEMBL492052 | — | EC50 | = | 9740.0 | nM | 5.01 |
| CHEMBL487497 | — | EC50 | = | 16000.0 | nM | 4.80 |