Assay Detail
Binding
CHEMBL995893
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Kca2.3 channel expressed in HEK293 cells by electrophysiology assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Small conductance calcium-activated potassium channel protein 3 (CHEMBL3381) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Preliminary SAR studies on non-apamin-displacing 4-(aminomethylaryl)pyrrazolopyrimidine K(Ca) channel blockers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.41 | 10.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL525408 | APAMIN | — | 1 | 10.19 |
| CHEMBL472452 | — | — | 1 | 6.24 |
| CHEMBL452406 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL525408 | APAMIN | IC50 | = | 0.064 | nM | 10.19 |
| CHEMBL472452 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL452406 | — | IC50 | = | 1600.0 | nM | 5.80 |