Assay Detail
Binding
CHEMBL995941
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Inhibition of 6-His tagged recombinant c-Myc353-437 gene binding to Max(S) protein assessed as disruption of heterodimer formation by circular dichroism assay
12
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of novel Myc-Max heterodimer disruptors with a three-dimensional pharmacophore model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.68 | 5.34 |
| Activity | 6 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL453935 | — | — | 1 | 5.34 |
| CHEMBL490677 | — | — | 1 | 5.00 |
| CHEMBL255556 | — | — | 1 | 4.64 |
| CHEMBL490486 | — | — | 1 | 4.42 |
| CHEMBL201467 | — | — | 1 | 4.39 |
| CHEMBL443375 | — | — | 1 | 4.31 |
| CHEMBL487697 | — | — | 1 | - |
| CHEMBL506666 | — | — | 1 | - |
| CHEMBL491273 | — | — | 1 | - |
| CHEMBL491274 | — | — | 1 | - |
| CHEMBL491275 | — | — | 1 | - |
| CHEMBL489096 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL453935 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL490677 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL255556 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL490486 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL201467 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL443375 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL487697 | — | Activity | - | — | - | |
| CHEMBL506666 | — | Activity | - | — | - | |
| CHEMBL491273 | — | Activity | = | 10.0 | uM | - |
| CHEMBL491274 | — | Activity | = | 25.0 | uM | - |
| CHEMBL491275 | — | Activity | = | 19.0 | uM | - |
| CHEMBL489096 | — | Activity | = | 45.0 | uM | - |