Assay Detail
Binding
CHEMBL996085
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Inhibition of human recombinant PTP1B
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 4.78 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL526644 | — | — | 1 | 5.82 |
| CHEMBL502539 | — | — | 1 | 5.60 |
| CHEMBL499061 | — | — | 1 | 5.12 |
| CHEMBL499329 | — | — | 1 | 5.03 |
| CHEMBL525812 | — | — | 1 | 5.01 |
| CHEMBL527109 | — | — | 1 | 4.95 |
| CHEMBL526369 | — | — | 1 | 4.94 |
| CHEMBL525078 | — | — | 1 | 4.93 |
| CHEMBL502013 | — | — | 1 | 4.84 |
| CHEMBL502540 | — | — | 1 | 4.81 |
| CHEMBL502815 | — | — | 1 | 4.73 |
| CHEMBL500677 | — | — | 1 | 4.71 |
| CHEMBL502006 | — | — | 1 | 4.71 |
| CHEMBL526177 | — | — | 1 | 4.59 |
| CHEMBL498473 | — | — | 1 | 4.48 |
| CHEMBL526866 | — | — | 1 | 4.43 |
| CHEMBL497509 | — | — | 1 | 4.42 |
| CHEMBL502014 | — | — | 1 | 4.26 |
| CHEMBL498474 | — | — | 1 | 4.20 |
| CHEMBL502257 | — | — | 1 | 4.01 |
| CHEMBL446483 | — | — | 1 | - |
| CHEMBL497510 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL526644 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL502539 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL499061 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL499329 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL525812 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL527109 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL526369 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL525078 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL502013 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL502540 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL502815 | — | IC50 | = | 18800.0 | nM | 4.73 |
| CHEMBL500677 | — | IC50 | = | 19300.0 | nM | 4.71 |
| CHEMBL502006 | — | IC50 | = | 19400.0 | nM | 4.71 |
| CHEMBL526177 | — | IC50 | = | 25700.0 | nM | 4.59 |
| CHEMBL498473 | — | IC50 | = | 32800.0 | nM | 4.48 |
| CHEMBL526866 | — | IC50 | = | 37100.0 | nM | 4.43 |
| CHEMBL497509 | — | IC50 | = | 38200.0 | nM | 4.42 |
| CHEMBL502014 | — | IC50 | = | 54900.0 | nM | 4.26 |
| CHEMBL498474 | — | IC50 | = | 63100.0 | nM | 4.20 |
| CHEMBL502257 | — | IC50 | = | 96700.0 | nM | 4.01 |
| CHEMBL446483 | — | IC50 | = | 156600.0 | nM | - |
| CHEMBL497510 | — | IC50 | > | 300000.0 | nM | - |