Assay Detail
Functional
CHEMBL996141
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Neuroprotective activity against human SH-SY5Y cells assessed as inhibition of MPP+-induced cell death
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SH-SY5Y |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-lineage kinase 1 crystallography, and oral in vivo activity in 1-methyl-4-phenyltetrahydropyridine models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.72 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL290352 | CEP-1347 | 3.0 | 1 | 8.28 |
| CHEMBL460989 | — | — | 1 | 7.50 |
| CHEMBL460990 | — | — | 1 | 7.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL290352 | CEP-1347 | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL460989 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL460990 | — | IC50 | = | 43.0 | nM | 7.37 |