Assay Detail
Functional
CHEMBL996239
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against wild type HIV1 NL4-3 infected in MT4 cells after 6 days by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
In vitro antiviral activity and cross-resistance profile of PL-100, a novel protease inhibitor of human immunodeficiency virus type 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 7.63 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1163 | ATAZANAVIR | 4.0 | 1 | 8.40 |
| CHEMBL114 | SAQUINAVIR | 4.0 | 1 | 7.92 |
| CHEMBL168640 | PPL-100 | 1.0 | 1 | 7.80 |
| CHEMBL729 | LOPINAVIR | 4.0 | 1 | 7.72 |
| CHEMBL584 | NELFINAVIR | 4.0 | 1 | 7.54 |
| CHEMBL116 | AMPRENAVIR | 4.0 | 1 | 7.29 |
| CHEMBL163 | RITONAVIR | 4.0 | 1 | 7.21 |
| CHEMBL5483011 | INDINAVIR | 3.0 | 1 | 7.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1163 | ATAZANAVIR | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL114 | SAQUINAVIR | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL168640 | PPL-100 | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL729 | LOPINAVIR | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL584 | NELFINAVIR | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL116 | AMPRENAVIR | EC50 | = | 51.0 | nM | 7.29 |
| CHEMBL163 | RITONAVIR | EC50 | = | 61.0 | nM | 7.21 |
| CHEMBL5483011 | INDINAVIR | EC50 | = | 67.0 | nM | 7.17 |