Assay Detail
Functional
CHEMBL996247
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Antiviral activity against wild type HIV1 NL4-3 in HEK293 cells after 48 hrs by replication-deffective luciferase reporter gene-based phenotypic assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | HEK293 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
In vitro antiviral activity and cross-resistance profile of PL-100, a novel protease inhibitor of human immunodeficiency virus type 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 8.39 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1163 | ATAZANAVIR | 4.0 | 1 | 8.82 |
| CHEMBL114 | SAQUINAVIR | 4.0 | 1 | 8.74 |
| CHEMBL729 | LOPINAVIR | 4.0 | 1 | 8.55 |
| CHEMBL168640 | PPL-100 | 1.0 | 1 | 8.28 |
| CHEMBL584 | NELFINAVIR | 4.0 | 1 | 8.24 |
| CHEMBL5483011 | INDINAVIR | 3.0 | 1 | 8.11 |
| CHEMBL116 | AMPRENAVIR | 4.0 | 1 | 7.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1163 | ATAZANAVIR | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL114 | SAQUINAVIR | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL729 | LOPINAVIR | EC50 | = | 2.8 | nM | 8.55 |
| CHEMBL168640 | PPL-100 | EC50 | = | 5.3 | nM | 8.28 |
| CHEMBL584 | NELFINAVIR | EC50 | = | 5.8 | nM | 8.24 |
| CHEMBL5483011 | INDINAVIR | EC50 | = | 7.8 | nM | 8.11 |
| CHEMBL116 | AMPRENAVIR | EC50 | = | 10.7 | nM | 7.97 |