Assay Detail
Functional
CHEMBL996436
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human Ketr3 cells after 96 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KETR3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Phelligridins C-F: cytotoxic pyrano[4,3-c][2]benzopyran-1,6-dione and furo[3,2-c]pyran-4-one derivatives from the fungus Phellinus igniarius.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.09 | 8.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 8.31 |
| CHEMBL218423 | PHELLIGRIDIN D | — | 1 | 7.05 |
| CHEMBL520568 | PHELLIGRIDIN C | — | 1 | 7.03 |
| CHEMBL470046 | PHELLIGRIDIN B | — | 1 | 6.84 |
| CHEMBL452722 | HISPOLON | — | 1 | 6.69 |
| CHEMBL75390 | — | — | 1 | 6.61 |
| CHEMBL446850 | PHELLIGRIDIN A | — | 1 | - |
| CHEMBL236399 | PHELLIGRIDIN E | — | 1 | - |
| CHEMBL488197 | PHELLIGRIDIN F | — | 1 | - |
| CHEMBL487596 | INOSCAVIN A | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL84 | TOPOTECAN | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL218423 | PHELLIGRIDIN D | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL520568 | PHELLIGRIDIN C | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL470046 | PHELLIGRIDIN B | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL452722 | HISPOLON | IC50 | = | 206.0 | nM | 6.69 |
| CHEMBL75390 | — | IC50 | = | 245.0 | nM | 6.61 |
| CHEMBL446850 | PHELLIGRIDIN A | IC50 | > | 192.0 | nM | - |
| CHEMBL236399 | PHELLIGRIDIN E | IC50 | > | 105.0 | nM | - |
| CHEMBL488197 | PHELLIGRIDIN F | IC50 | > | 104.0 | nM | - |
| CHEMBL487596 | INOSCAVIN A | IC50 | > | 108.0 | nM | - |