Assay Detail
Binding
CHEMBL996935
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Inhibition of CYP26A1 in human MCF7 cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel azolyl-(phenylmethyl)]aryl/heteroarylamines: potent CYP26 inhibitors and enhancers of all-trans retinoic acid activity in neuroblastoma cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.65 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL224305 | — | — | 1 | 8.30 |
| CHEMBL518482 | — | — | 1 | 6.30 |
| CHEMBL518642 | — | — | 1 | 6.05 |
| CHEMBL517904 | — | — | 1 | 6.00 |
| CHEMBL460780 | — | — | 1 | 5.82 |
| CHEMBL462468 | — | — | 1 | 5.60 |
| CHEMBL360771 | — | — | 1 | 5.48 |
| CHEMBL517109 | — | — | 1 | 5.35 |
| CHEMBL450523 | — | — | 1 | 5.30 |
| CHEMBL459925 | — | — | 1 | 5.30 |
| CHEMBL460357 | — | — | 1 | 5.16 |
| CHEMBL389433 | LIAROZOLE | 2.0 | 1 | 5.16 |
| CHEMBL460130 | — | — | 1 | 4.82 |
| CHEMBL449460 | — | — | 1 | 4.46 |
| CHEMBL461860 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL224305 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL518482 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL518642 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL517904 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL460780 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL462468 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL360771 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL517109 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL450523 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL459925 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL460357 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL389433 | LIAROZOLE | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL460130 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL449460 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL461860 | — | IC50 | > | 50000.0 | nM | - |