Assay Detail
Binding
CHEMBL997155
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Inhibition of dynamin 1-mediated endocytosis internalization of Tf-A594 in human U2OS cells pretreated for 30 mins
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | U2OS |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibition of dynamin mediated endocytosis by the dynoles--synthesis and functional activity of a family of indoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.85 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL483059 | — | — | 1 | 5.30 |
| CHEMBL496625 | — | — | 1 | 4.97 |
| CHEMBL523731 | — | — | 1 | 4.88 |
| CHEMBL496824 | — | — | 1 | 4.84 |
| CHEMBL496626 | — | — | 1 | 4.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL483059 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL496625 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL523731 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL496824 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL496626 | — | IC50 | = | 58200.0 | nM | 4.24 |