Assay Detail
Binding
CHEMBL997161
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity of wild type chicken N-terminal His-tagged cSrc expressed in Escherichia coli BL21 (DE3) at 50 uM
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Gallus gallus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL3655) ↗| Type | SINGLE PROTEIN |
| Organism | Gallus gallus |
Publication
Hybrid compound design to overcome the gatekeeper T338M mutation in cSrc.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 4.52 | 4.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL522387 | — | — | 1 | 4.58 |
| CHEMBL498947 | — | — | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL522387 | — | Kd | = | 26000.0 | nM | 4.58 |
| CHEMBL498947 | — | Kd | = | 35000.0 | nM | 4.46 |