Assay Detail
Functional
CHEMBL997204
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity as reduced parasitaemia after 72 hrs against chloroquine-resistant Plasmodium falciparum K1 infected human O+ erythrocytes by DNA stain without pepstatin
90
Total Activities
90
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antimalarial activity of thiosemicarbazones and purine derived nitriles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 90 | 4.57 | 4.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL497008 | — | — | 1 | 4.96 |
| CHEMBL495591 | — | — | 1 | 4.92 |
| CHEMBL522212 | — | — | 1 | 4.75 |
| CHEMBL524049 | — | — | 1 | 4.62 |
| CHEMBL522389 | — | — | 1 | 4.52 |
| CHEMBL574590 | — | — | 1 | 4.52 |
| CHEMBL524803 | — | — | 1 | 4.52 |
| CHEMBL582971 | — | — | 1 | 4.52 |
| CHEMBL521904 | — | — | 1 | 4.52 |
| CHEMBL523210 | — | — | 1 | 4.52 |
| CHEMBL497009 | — | — | 1 | 4.52 |
| CHEMBL521546 | — | — | 1 | 4.52 |
| CHEMBL404938 | — | — | 1 | 4.52 |
| CHEMBL494171 | — | — | 1 | 4.52 |
| CHEMBL521727 | — | — | 1 | 4.52 |
| CHEMBL512103 | — | — | 1 | 4.52 |
| CHEMBL468291 | — | — | 1 | 4.52 |
| CHEMBL492791 | — | — | 1 | 4.52 |
| CHEMBL524006 | — | — | 1 | 4.52 |
| CHEMBL523363 | — | — | 1 | 4.52 |
| CHEMBL494841 | — | — | 1 | 4.52 |
| CHEMBL447021 | — | — | 1 | 4.52 |
| CHEMBL497237 | — | — | 1 | - |
| CHEMBL522512 | — | — | 1 | - |
| CHEMBL525165 | — | — | 1 | - |
| CHEMBL497435 | — | — | 1 | - |
| CHEMBL497235 | — | — | 1 | - |
| CHEMBL497234 | — | — | 1 | - |
| CHEMBL497018 | — | — | 1 | - |
| CHEMBL524075 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL497008 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL495591 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL522212 | — | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL524049 | — | EC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL521904 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL574590 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL524803 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL582971 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL523210 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL497009 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL522389 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL521546 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL404938 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL494171 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL494841 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL523363 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL524006 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL447021 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL492791 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL468291 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL512103 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL521727 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL495015 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL494845 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL524810 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL497817 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL584314 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL497620 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL524619 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL496199 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL181504 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL402465 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL495614 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL407264 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL429858 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL258588 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL495016 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL495017 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL495802 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL495803 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL523733 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL496404 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL524075 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL497018 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL497234 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL497235 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL497435 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL525165 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL522512 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL497237 | — | EC50 | > | 30000.0 | nM | - |