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Compound Detail

CHEMBL522212

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N#Cc1nc(NCc2ccc(-c3cccc(Cl)c3)cc2)c2ncn(CCCO)c2n1

Basic Information

ChEMBL ID CHEMBL522212
Phase Preclinical
Structure Type MOL
InChI Key XVDFZQSDJGDASX-UHFFFAOYSA-N
1
Targets
4
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

418.9
MW (Da)
4.01
ALogP
7
HBA
2
HBD
99.7
PSA (Ų)
0.47
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H19ClN6O
MW 418.89
Aromatic Rings 4
Heavy Atoms 30
NP-Likeness -1.21

Activity Summary

EC50 4 meas. best 4.85

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Plasmodium falciparum
CHEMBL364
EC50 4.85 4.75 14000.0 4

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
19447616 10.1016/j.bmcl.2009.04.142 Plasmodium falciparum 4

Data from ChEMBL 36 via Core Engine