Assay Detail
Binding
CHEMBL997396
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Inhibition of human recombinant PKCalpha
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Phenylethanoid glycosides from Digitalis purpurea and Penstemon linarioides with PKCalpha-inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.21 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL481635 | CALCEOLARIOSIDE A | — | 1 | 6.22 |
| CHEMBL504363 | FORSYTHIASIDE | — | 1 | 5.72 |
| CHEMBL518414 | CALCEOLARIOSIDE B | — | 1 | 5.34 |
| CHEMBL444478 | ACETOSIDE | 2.0 | 1 | 5.03 |
| CHEMBL452413 | PLANTAINOSIDE D | — | 1 | 4.83 |
| CHEMBL450121 | LEUCOSCEPTOSIDE A | — | 1 | 4.72 |
| CHEMBL499145 | POLIUMOSIDE | — | 1 | 4.61 |
| CHEMBL506920 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL481635 | CALCEOLARIOSIDE A | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL504363 | FORSYTHIASIDE | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL518414 | CALCEOLARIOSIDE B | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL444478 | ACETOSIDE | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL452413 | PLANTAINOSIDE D | IC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL450121 | LEUCOSCEPTOSIDE A | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL499145 | POLIUMOSIDE | IC50 | = | 24400.0 | nM | 4.61 |
| CHEMBL506920 | — | IC50 | = | 125000.0 | nM | - |