Assay Detail
Binding
CHEMBL997702
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant LFA1/ICAM1-IG interaction by time-resolved fluorimetry method
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Intercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2 (CHEMBL2096661) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Structure-activity relationship of ortho- and meta-phenol based LFA-1 ICAM inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 7.86 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL452882 | — | — | 1 | 9.40 |
| CHEMBL502756 | — | — | 1 | 9.22 |
| CHEMBL526564 | — | — | 1 | 8.74 |
| CHEMBL521708 | — | — | 1 | 8.70 |
| CHEMBL496945 | — | — | 1 | 8.68 |
| CHEMBL497978 | — | — | 1 | 8.60 |
| CHEMBL487705 | — | — | 1 | 8.60 |
| CHEMBL502789 | — | — | 1 | 8.52 |
| CHEMBL443467 | — | — | 1 | 8.47 |
| CHEMBL446300 | — | — | 1 | 8.47 |
| CHEMBL524347 | — | — | 1 | 8.43 |
| CHEMBL495906 | — | — | 1 | 8.41 |
| CHEMBL502512 | — | — | 1 | 8.40 |
| CHEMBL496314 | — | — | 1 | 8.05 |
| CHEMBL495518 | — | — | 1 | 8.02 |
| CHEMBL521385 | — | — | 1 | 8.01 |
| CHEMBL496106 | — | — | 1 | 7.96 |
| CHEMBL499029 | — | — | 1 | 7.75 |
| CHEMBL524354 | — | — | 1 | 7.75 |
| CHEMBL500111 | — | — | 1 | 7.62 |
| CHEMBL497358 | — | — | 1 | 7.47 |
| CHEMBL501977 | — | — | 1 | 7.29 |
| CHEMBL501430 | — | — | 1 | 7.28 |
| CHEMBL496738 | — | — | 1 | 7.26 |
| CHEMBL496105 | — | — | 1 | 7.17 |
| CHEMBL487496 | — | — | 1 | 7.16 |
| CHEMBL501166 | — | — | 1 | 7.16 |
| CHEMBL487291 | — | — | 1 | 6.66 |
| CHEMBL524292 | — | — | 1 | 6.28 |
| CHEMBL526179 | — | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL452882 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL502756 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL526564 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL521708 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL496945 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL497978 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL487705 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL502789 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL443467 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL446300 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL524347 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL495906 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL502512 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL496314 | — | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL495518 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL521385 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL496106 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL499029 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL524354 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL500111 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL497358 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL501977 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL501430 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL496738 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL496105 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL487496 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL501166 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL487291 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL524292 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL526179 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL501976 | — | IC50 | = | 860.0 | nM | 6.07 |