Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL997841

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of yeast alpha glucosidase in phosphate buffer after 0.5 hrs by spectrophotometry
ChEMBL ↗
86
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Saccharomyces
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

Synthesis, inhibitory activities, and QSAR study of xanthone derivatives as alpha-glucosidase inhibitors.
Liu Y, Ke Z, Cui J, Chen WH, Ma L, Wang B.
Bioorg Med Chem (2008) 16 : 7185 -7192
PubMed 18632275 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 86 4.55 5.24

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL227226 — — 2 5.24
CHEMBL479043 — — 2 5.23
CHEMBL478410 — — 2 5.20
CHEMBL227227 — — 2 5.10
CHEMBL517358 — — 2 5.08
CHEMBL227224 — — 2 5.03
CHEMBL361025 — — 2 4.83
CHEMBL505898 — — 2 4.77
CHEMBL387528 — — 2 4.70
CHEMBL226546 — — 2 4.56
CHEMBL477359 — — 2 4.53
CHEMBL467155 — — 2 4.50
CHEMBL226547 — — 2 4.50
CHEMBL226595 — — 2 4.46
CHEMBL387529 — — 2 4.40
CHEMBL468353 — — 2 4.38
CHEMBL468371 — — 2 4.33
CHEMBL469066 — — 2 4.30
CHEMBL467547 — — 2 4.28
CHEMBL511923 — — 2 4.21
CHEMBL501678 — — 2 4.20
CHEMBL231904 — — 2 4.18
CHEMBL517351 — — 2 4.17
CHEMBL469039 — — 2 4.09
CHEMBL494104 — — 2 4.04
CHEMBL468401 — — 2 4.01
CHEMBL459695 — — 2 -
CHEMBL511070 — — 2 -
CHEMBL187368 — — 2 -
CHEMBL388525 — — 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL227226 — IC50 = 5800.0 nM 5.24
CHEMBL479043 — IC50 = 5900.0 nM 5.23
CHEMBL478410 — IC50 = 6300.0 nM 5.20
CHEMBL227227 — IC50 = 8000.0 nM 5.10
CHEMBL517358 — IC50 = 8300.0 nM 5.08
CHEMBL227224 — IC50 = 9300.0 nM 5.03
CHEMBL361025 — IC50 = 14700.0 nM 4.83
CHEMBL505898 — IC50 = 17100.0 nM 4.77
CHEMBL387528 — IC50 = 20100.0 nM 4.70
CHEMBL226546 — IC50 = 27800.0 nM 4.56
CHEMBL477359 — IC50 = 29700.0 nM 4.53
CHEMBL226547 — IC50 = 31300.0 nM 4.50
CHEMBL467155 — IC50 = 31900.0 nM 4.50
CHEMBL226595 — IC50 = 34900.0 nM 4.46
CHEMBL387529 — IC50 = 39900.0 nM 4.40
CHEMBL468353 — IC50 = 41500.0 nM 4.38
CHEMBL468371 — IC50 = 46500.0 nM 4.33
CHEMBL469066 — IC50 = 49700.0 nM 4.30
CHEMBL467547 — IC50 = 53000.0 nM 4.28
CHEMBL511923 — IC50 = 61800.0 nM 4.21
CHEMBL501678 — IC50 = 63500.0 nM 4.20
CHEMBL231904 — IC50 = 66600.0 nM 4.18
CHEMBL517351 — IC50 = 67300.0 nM 4.17
CHEMBL469039 — IC50 = 81800.0 nM 4.09
CHEMBL494104 — IC50 = 91500.0 nM 4.04
CHEMBL468401 — IC50 = 98200.0 nM 4.01
CHEMBL469066 — IC50 = 19952623.15 nM -
CHEMBL494104 — IC50 = 10964781.96 nM -
CHEMBL459695 — IC50 = 7585775.75 nM -
CHEMBL459695 — IC50 = 131400.0 nM -
CHEMBL469039 — IC50 = 12302687.71 nM -
CHEMBL468353 — IC50 = 23988329.19 nM -
CHEMBL361025 — IC50 = 67608297.54 nM -
CHEMBL505898 — IC50 = 58884365.54 nM -
CHEMBL467155 — IC50 = 31622776.6 nM -
CHEMBL511070 — IC50 = 7244359.6 nM -
CHEMBL511070 — IC50 = 138900.0 nM -
CHEMBL468371 — IC50 = 21379620.9 nM -
CHEMBL468822 — IC50 = 9120108.39 nM -
CHEMBL188014 — IC50 = 5754399.37 nM -
CHEMBL512123 — IC50 = 8709635.9 nM -
CHEMBL468231 — IC50 = 113800.0 nM -
CHEMBL468231 — IC50 = 8709635.9 nM -
CHEMBL448228 — IC50 = 120900.0 nM -
CHEMBL448228 — IC50 = 8317637.71 nM -
CHEMBL468232 — IC50 = 8128305.16 nM -
CHEMBL468557 — IC50 = 7762471.17 nM -
CHEMBL468822 — IC50 = 110800.0 nM -
CHEMBL468557 — IC50 = 130100.0 nM -
CHEMBL188014 — IC50 = 172900.0 nM -