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Assay Detail

CHEMBL997858

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Functional
Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2
ChEMBL ↗
53
Total Activities
27
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364) ↗
Type ORGANISM
Organism Plasmodium falciparum

Publication

Novel 4-aminoquinolines active against chloroquine-resistant and sensitive P. falciparum strains that also inhibit botulinum serotype A.
Solaja BA, Opsenica D, Smith KS, Milhous WK, Terzić N, Opsenica I, Burnett JC, Nuss J, Gussio R, Bavari S.
J Med Chem (2008) 51 : 4388 -4391
PubMed 18637666 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 27 7.12 8.47
IC90 26 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL446050 — — 2 8.47
CHEMBL416956 MEFLOQUINE 4.0 2 8.30
CHEMBL500206 — — 2 8.24
CHEMBL269671 ARTEMISININ 3.0 2 8.17
CHEMBL467809 — — 2 8.08
CHEMBL450398 — — 2 7.94
CHEMBL512475 — — 2 7.92
CHEMBL468844 — — 2 7.80
CHEMBL501065 — — 2 7.75
CHEMBL513526 — — 2 7.47
CHEMBL446916 — — 2 7.31
CHEMBL513865 — — 2 7.11
CHEMBL468860 — — 2 7.08
CHEMBL500540 — — 2 6.97
CHEMBL450654 — — 2 6.96
CHEMBL449539 — — 2 6.88
CHEMBL454039 — — 2 6.86
CHEMBL468845 — — 2 6.80
CHEMBL502299 — — 2 6.68
CHEMBL468588 — — 2 6.59
CHEMBL468426 — — 2 6.47
CHEMBL76 CHLOROQUINE 4.0 2 6.41
CHEMBL513343 — — 2 6.32
CHEMBL468427 — — 2 6.29
CHEMBL468428 — — 2 6.06
CHEMBL468843 — — 2 6.05
CHEMBL451154 — — 1 5.14

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL446050 — IC50 = 3.38 nM 8.47
CHEMBL416956 MEFLOQUINE IC50 = 4.96 nM 8.30
CHEMBL500206 — IC50 = 5.74 nM 8.24
CHEMBL269671 ARTEMISININ IC50 = 6.7 nM 8.17
CHEMBL467809 — IC50 = 8.4 nM 8.08
CHEMBL450398 — IC50 = 11.38 nM 7.94
CHEMBL512475 — IC50 = 12.1 nM 7.92
CHEMBL468844 — IC50 = 15.66 nM 7.80
CHEMBL501065 — IC50 = 17.83 nM 7.75
CHEMBL513526 — IC50 = 33.66 nM 7.47
CHEMBL446916 — IC50 = 48.85 nM 7.31
CHEMBL513865 — IC50 = 78.15 nM 7.11
CHEMBL468860 — IC50 = 83.21 nM 7.08
CHEMBL500540 — IC50 = 107.72 nM 6.97
CHEMBL450654 — IC50 = 111.03 nM 6.96
CHEMBL449539 — IC50 = 130.95 nM 6.88
CHEMBL454039 — IC50 = 139.61 nM 6.86
CHEMBL468845 — IC50 = 159.71 nM 6.80
CHEMBL502299 — IC50 = 208.98 nM 6.68
CHEMBL468588 — IC50 = 253.81 nM 6.59
CHEMBL468426 — IC50 = 337.19 nM 6.47
CHEMBL76 CHLOROQUINE IC50 = 392.09 nM 6.41
CHEMBL513343 — IC50 = 484.51 nM 6.32
CHEMBL468427 — IC50 = 517.72 nM 6.29
CHEMBL468428 — IC50 = 877.99 nM 6.06
CHEMBL468843 — IC50 = 884.29 nM 6.05
CHEMBL451154 — IC50 = 7191.35 nM 5.14
CHEMBL416956 MEFLOQUINE IC90 = 14.7 nM -
CHEMBL468428 — IC90 = 1358.8 nM -
CHEMBL468843 — IC90 = 1408.66 nM -
CHEMBL468844 — IC90 = 30.96 nM -
CHEMBL513526 — IC90 = 56.09 nM -
CHEMBL468845 — IC90 = 310.82 nM -
CHEMBL468588 — IC90 = 396.84 nM -
CHEMBL512475 — IC90 = 20.05 nM -
CHEMBL449539 — IC90 = 167.69 nM -
CHEMBL513865 — IC90 = 113.35 nM -
CHEMBL468860 — IC90 = 132.3 nM -
CHEMBL76 CHLOROQUINE IC90 = 529.86 nM -
CHEMBL269671 ARTEMISININ IC90 = 11.5 nM -
CHEMBL500540 — IC90 = 563.15 nM -
CHEMBL467809 — IC90 = 15.22 nM -
CHEMBL450398 — IC90 = 32.5 nM -
CHEMBL446916 — IC90 = 70.57 nM -
CHEMBL446050 — IC90 = 6.74 nM -
CHEMBL450654 — IC90 = 147.21 nM -
CHEMBL454039 — IC90 = 1176.5 nM -
CHEMBL502299 — IC90 = 1851.51 nM -
CHEMBL501065 — IC90 = 24.6 nM -
CHEMBL500206 — IC90 = 11.18 nM -