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Assay Detail

CHEMBL997884

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of COX1 in human whole blood
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Tissue Blood
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Prostaglandin G/H synthase 1 (CHEMBL221)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

New NSAIDs-NO hybrid molecules with antiproliferative properties on human prostatic cancer cell lines.
Bézière N, Goossens L, Pommery J, Vezin H, Touati N, Hénichart JP, Pommery N.
Bioorg Med Chem Lett (2008) 18 : 4655 -4657
PubMed 18667313 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 6.06 6.48

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL571 KETOPROFEN 4.0 1 6.48
CHEMBL444396 1 6.35
CHEMBL497677 1 6.32
CHEMBL956 SUPROFEN 4.0 1 6.25
CHEMBL526643 1 6.24
CHEMBL497507 1 6.24
CHEMBL497859 1 6.24
CHEMBL497858 1 6.22
CHEMBL1316 CARPROFEN 4.0 1 4.23
CHEMBL498529 1 -
CHEMBL497678 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL571 KETOPROFEN IC50 = 330.0 nM 6.48
CHEMBL444396 IC50 = 450.0 nM 6.35
CHEMBL497677 IC50 = 480.0 nM 6.32
CHEMBL956 SUPROFEN IC50 = 560.0 nM 6.25
CHEMBL526643 IC50 = 570.0 nM 6.24
CHEMBL497507 IC50 = 580.0 nM 6.24
CHEMBL497859 IC50 = 580.0 nM 6.24
CHEMBL497858 IC50 = 600.0 nM 6.22
CHEMBL1316 CARPROFEN IC50 = 59000.0 nM 4.23
CHEMBL498529 IC50 = 123000.0 nM -
CHEMBL497678 IC50 = 110000.0 nM -