Assay Detail
Functional
CHEMBL997910
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Cytotoxicity against human RPMI8402 cells after 4 days by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RPMI 8402 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Syntheses and biological evaluation of topoisomerase I-targeting agents related to 11-[2-(N,N-dimethylamino)ethyl]-2,3-dimethoxy-8,9-methylenedioxy-11H-isoquino[4,3-c]cinnolin-12-one (ARC-31).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.86 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL71086 | — | — | 1 | 8.70 |
| CHEMBL70790 | — | — | 1 | 8.70 |
| CHEMBL496473 | — | — | 1 | 8.52 |
| CHEMBL501193 | — | — | 1 | 8.52 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.30 |
| CHEMBL256099 | — | — | 1 | 7.89 |
| CHEMBL255716 | — | — | 1 | 7.48 |
| CHEMBL527115 | — | — | 1 | 7.40 |
| CHEMBL501192 | — | — | 1 | 7.35 |
| CHEMBL257572 | — | — | 1 | 7.19 |
| CHEMBL257629 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL71086 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL70790 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL496473 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL501193 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL256099 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL255716 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL527115 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL501192 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL257572 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL257629 | — | IC50 | = | 400.0 | nM | 6.40 |