Assay Detail
Functional
CHEMBL997911
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human camptothecin-resistant CPT-K5 cells after 4 days by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CPT-K5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Syntheses and biological evaluation of topoisomerase I-targeting agents related to 11-[2-(N,N-dimethylamino)ethyl]-2,3-dimethoxy-8,9-methylenedioxy-11H-isoquino[4,3-c]cinnolin-12-one (ARC-31).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.76 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL501193 | — | — | 1 | 6.64 |
| CHEMBL496473 | — | — | 1 | 6.52 |
| CHEMBL71086 | — | — | 1 | 6.13 |
| CHEMBL70790 | — | — | 1 | 6.05 |
| CHEMBL256099 | — | — | 1 | 5.89 |
| CHEMBL255716 | — | — | 1 | 5.66 |
| CHEMBL501192 | — | — | 1 | 5.48 |
| CHEMBL257572 | — | — | 1 | 5.24 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 4.21 |
| CHEMBL257629 | — | — | 1 | - |
| CHEMBL527115 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL501193 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL496473 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL71086 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL70790 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL256099 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL255716 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL501192 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL257572 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL257629 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL527115 | — | IC50 | > | 10000.0 | nM | - |