Assay Detail
Functional
CHEMBL997913
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human multidrug resistant MDR1 overexpressing human KBV1 cells after 4 days by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB-V1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Syntheses and biological evaluation of topoisomerase I-targeting agents related to 11-[2-(N,N-dimethylamino)ethyl]-2,3-dimethoxy-8,9-methylenedioxy-11H-isoquino[4,3-c]cinnolin-12-one (ARC-31).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.30 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL71086 | — | — | 1 | 8.40 |
| CHEMBL496473 | — | — | 1 | 8.15 |
| CHEMBL70790 | — | — | 1 | 7.82 |
| CHEMBL256099 | — | — | 1 | 7.75 |
| CHEMBL501193 | — | — | 1 | 7.64 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.60 |
| CHEMBL501192 | — | — | 1 | 7.12 |
| CHEMBL527115 | — | — | 1 | 7.07 |
| CHEMBL255716 | — | — | 1 | 6.75 |
| CHEMBL257572 | — | — | 1 | 6.55 |
| CHEMBL257629 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL71086 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL496473 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL70790 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL256099 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL501193 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL501192 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL527115 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL255716 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL257572 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL257629 | — | IC50 | = | 3300.0 | nM | 5.48 |