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Assay Detail

CHEMBL998017

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Functional
Agonist activity at androgen receptor
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Androgen receptor (CHEMBL1871)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Nonsteroidal selective androgen receptor modulators (SARMs): dissociating the anabolic and androgenic activities of the androgen receptor for therapeutic benefit.
Mohler ML, Bohl CE, Jones A, Coss CC, Narayanan R, He Y, Hwang DJ, Dalton JT, Miller DD.
J Med Chem (2009) 52 : 3597 -3617
PubMed 19432422 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 15 8.52 9.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL296323 1 9.52
CHEMBL233773 1 9.35
CHEMBL229861 1 9.05
CHEMBL467790 1 8.96
CHEMBL436784 1 8.82
CHEMBL467888 LGD-2941 1.0 1 8.82
CHEMBL333745 1 8.78
CHEMBL512283 1 8.77
CHEMBL229264 1 8.68
CHEMBL125236 1 8.40
CHEMBL3084525 1 8.30
CHEMBL124718 1 8.21
CHEMBL224263 1 8.15
CHEMBL467887 1 7.83
CHEMBL242469 1 6.20

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL296323 Ki = 0.3 nM 9.52
CHEMBL233773 Ki = 0.45 nM 9.35
CHEMBL229861 Ki = 0.9 nM 9.05
CHEMBL467790 Ki = 1.1 nM 8.96
CHEMBL436784 Ki = 1.5 nM 8.82
CHEMBL467888 LGD-2941 Ki = 1.5 nM 8.82
CHEMBL333745 Ki = 1.65 nM 8.78
CHEMBL512283 Ki = 1.7 nM 8.77
CHEMBL229264 Ki = 2.1 nM 8.68
CHEMBL125236 Ki = 4.0 nM 8.40
CHEMBL3084525 Ki = 5.0 nM 8.30
CHEMBL124718 Ki = 6.1 nM 8.21
CHEMBL224263 Ki = 7.1 nM 8.15
CHEMBL467887 Ki = 14.9 nM 7.83
CHEMBL242469 Ki = 630.0 nM 6.20