Assay Detail
Binding
CHEMBL998034
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in HEK293 cells
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Rational design, synthesis, and pharmacological properties of new 1,8-naphthyridin-2(1H)-on-3-carboxamide derivatives as highly selective cannabinoid-2 receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 8.26 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL381689 | SR-144528 | — | 1 | 9.22 |
| CHEMBL467896 | — | — | 1 | 9.15 |
| CHEMBL466047 | — | — | 1 | 9.15 |
| CHEMBL466651 | — | — | 1 | 9.05 |
| CHEMBL466223 | — | — | 1 | 8.72 |
| CHEMBL508336 | — | — | 1 | 8.66 |
| CHEMBL467475 | — | — | 1 | 8.52 |
| CHEMBL371214 | — | — | 1 | 8.52 |
| CHEMBL467681 | — | — | 1 | 8.24 |
| CHEMBL467476 | — | — | 1 | 8.11 |
| CHEMBL466623 | — | — | 1 | 8.10 |
| CHEMBL512063 | — | — | 1 | 8.05 |
| CHEMBL511253 | — | — | 1 | 7.66 |
| CHEMBL446993 | — | — | 1 | 7.51 |
| CHEMBL467680 | — | — | 1 | 7.40 |
| CHEMBL466429 | — | — | 1 | 7.16 |
| CHEMBL513298 | — | — | 1 | 7.16 |
| CHEMBL466428 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL381689 | SR-144528 | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL467896 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL466047 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL466651 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL466223 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL508336 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL467475 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL371214 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL467681 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL467476 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL466623 | — | Ki | = | 7.9 | nM | 8.10 |
| CHEMBL512063 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL511253 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL446993 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL467680 | — | Ki | = | 39.8 | nM | 7.40 |
| CHEMBL466429 | — | Ki | = | 69.8 | nM | 7.16 |
| CHEMBL513298 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL466428 | — | Ki | - | — | - |