Assay Detail
Binding
CHEMBL998470
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Displacement of [3H]Colchicine from pig biotinylated tubulin after 2 hrs by SPA
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
10-(2-oxo-2-phenylethylidene)-10H-anthracen-9-ones as highly active antimicrotubule agents: synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.19 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL455138 | — | — | 1 | 6.40 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 5.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL455138 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL107 | COLCHICINE | IC50 | = | 1060.0 | nM | 5.97 |