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Assay Detail

CHEMBL998511

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human BxPC3 cells after 3 days by MTT assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type BXPC-3
Confidence 1 — Organism
Curated By Autocuration

Target

BXPC-3 (CHEMBL614530)
Type CELL-LINE
Organism Homo sapiens

Publication

Structure-activity relationship analysis of novel derivatives of narciclasine (an Amaryllidaceae isocarbostyril derivative) as potential anticancer agents.
Ingrassia L, Lefranc F, Dewelle J, Pottier L, Mathieu V, Spiegl-Kreinecker S, Sauvage S, El Yazidi M, Dehoux M, Berger W, Van Quaquebeke E, Kiss R.
J Med Chem (2009) 52 : 1100 -1114
PubMed 19199649 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 28 6.51 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL515290 1 8.52
CHEMBL472729 1 8.40
CHEMBL472928 1 8.05
CHEMBL98745 NARCICLASINE 1 7.52
CHEMBL458338 1 7.52
CHEMBL472728 1 7.16
CHEMBL460528 1 6.40
CHEMBL514653 1 6.00
CHEMBL504922 1 5.52
CHEMBL474334 1 5.52
CHEMBL514507 1 5.22
CHEMBL526302 1 5.16
CHEMBL474530 1 5.10
CHEMBL474534 1 5.00
CHEMBL448011 1 -
CHEMBL517110 1 -
CHEMBL474533 1 -
CHEMBL515402 1 -
CHEMBL515744 1 -
CHEMBL502042 1 -
CHEMBL474736 1 -
CHEMBL475139 1 -
CHEMBL516233 1 -
CHEMBL475140 1 -
CHEMBL475342 1 -
CHEMBL522586 1 -
CHEMBL514295 1 -
CHEMBL489475 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL515290 IC50 = 3.0 nM 8.52
CHEMBL472729 IC50 = 4.0 nM 8.40
CHEMBL472928 IC50 = 9.0 nM 8.05
CHEMBL98745 NARCICLASINE IC50 = 30.0 nM 7.52
CHEMBL458338 IC50 = 30.0 nM 7.52
CHEMBL472728 IC50 = 70.0 nM 7.16
CHEMBL460528 IC50 = 400.0 nM 6.40
CHEMBL514653 IC50 = 1000.0 nM 6.00
CHEMBL504922 IC50 = 3000.0 nM 5.52
CHEMBL474334 IC50 = 3000.0 nM 5.52
CHEMBL514507 IC50 = 6000.0 nM 5.22
CHEMBL526302 IC50 = 7000.0 nM 5.16
CHEMBL474530 IC50 = 8000.0 nM 5.10
CHEMBL474534 IC50 = 10000.0 nM 5.00
CHEMBL448011 IC50 > 10000.0 nM -
CHEMBL517110 IC50 > 10000.0 nM -
CHEMBL474533 IC50 > 10000.0 nM -
CHEMBL515402 IC50 > 10000.0 nM -
CHEMBL515744 IC50 > 10000.0 nM -
CHEMBL502042 IC50 - -
CHEMBL474736 IC50 - -
CHEMBL475139 IC50 > 10000.0 nM -
CHEMBL516233 IC50 > 10000.0 nM -
CHEMBL475140 IC50 > 10000.0 nM -
CHEMBL475342 IC50 > 10000.0 nM -
CHEMBL522586 IC50 > 10000.0 nM -
CHEMBL514295 IC50 > 10000.0 nM -
CHEMBL489475 IC50 > 10000.0 nM -