Assay Detail
Binding
CHEMBL998555
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Inhibition of GST-fused p38alpha expressed in Escherichia coli
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
The identification of pyrazolo[1,5-a]pyridines as potent p38 kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.84 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL520564 | — | — | 1 | 7.30 |
| CHEMBL518890 | — | — | 1 | 7.16 |
| CHEMBL485745 | GW434756X | — | 1 | 6.92 |
| CHEMBL488183 | — | — | 1 | 6.85 |
| CHEMBL487581 | — | — | 1 | 6.82 |
| CHEMBL487780 | — | — | 1 | 6.82 |
| CHEMBL501070 | — | — | 1 | 6.82 |
| CHEMBL520563 | — | — | 1 | 6.82 |
| CHEMBL518917 | — | — | 1 | 6.80 |
| CHEMBL524530 | — | — | 1 | 6.80 |
| CHEMBL488184 | — | — | 1 | 6.77 |
| CHEMBL487781 | — | — | 1 | 6.70 |
| CHEMBL509189 | — | — | 1 | 6.62 |
| CHEMBL487577 | — | — | 1 | 6.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL520564 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL518890 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL485745 | GW434756X | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL488183 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL487581 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL487780 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL501070 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL520563 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL518917 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL524530 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL488184 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL487781 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL509189 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL487577 | — | IC50 | = | 280.0 | nM | 6.55 |