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Assay Detail

CHEMBL998569

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of LCK
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Tyrosine-protein kinase Lck (CHEMBL258)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Kinase array design, back to front: biaryl amides.
Baldwin I, Bamborough P, Haslam CG, Hunjan SS, Longstaff T, Mooney CJ, Patel S, Quinn J, Somers DO.
Bioorg Med Chem Lett (2008) 18 : 5285 -5289
PubMed 18789685 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 5.59 7.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL521887 1 7.16
CHEMBL497353 1 6.00
CHEMBL496129 1 5.70
CHEMBL497350 1 5.52
CHEMBL526639 1 5.52
CHEMBL485286 1 5.22
CHEMBL485285 1 5.10
CHEMBL523559 1 5.10
CHEMBL495729 1 5.00
CHEMBL497563 1 -
CHEMBL522579 1 -
CHEMBL521734 1 -
CHEMBL478649 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL521887 IC50 = 70.0 nM 7.16
CHEMBL497353 IC50 = 1000.0 nM 6.00
CHEMBL496129 IC50 = 2000.0 nM 5.70
CHEMBL497350 IC50 = 3000.0 nM 5.52
CHEMBL526639 IC50 = 3000.0 nM 5.52
CHEMBL485286 IC50 = 6000.0 nM 5.22
CHEMBL485285 IC50 = 8000.0 nM 5.10
CHEMBL523559 IC50 = 8000.0 nM 5.10
CHEMBL495729 IC50 = 10000.0 nM 5.00
CHEMBL497563 IC50 > 16000.0 nM -
CHEMBL522579 IC50 > 16000.0 nM -
CHEMBL521734 IC50 > 16000.0 nM -
CHEMBL478649 IC50 > 16000.0 nM -