Compound Detail
CHEMBL485286
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Basic Information
| ChEMBL ID | CHEMBL485286 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DMTJDVSGJMJVRQ-UHFFFAOYSA-N |
6
Targets
6
Activities
2
Assay Types
0
PK Parameters
13
Publications
0
Known Names
Molecular Properties
481.6
MW (Da)
5.52
ALogP
6
HBA
2
HBD
83.3
PSA (Ų)
0.39
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 7.52
Ki 1 meas. best 9.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mitogen-activated protein kinase 14 CHEMBL260 | Ki | 9.1 | 9.1 | 0.8 | 1 |
| Dual specificity mitogen-activated protein kinase kinase 1 CHEMBL3587 | IC50 | 7.52 | 7.52 | 30.0 | 1 |
| PBMC CHEMBL613107 | IC50 | 7.22 | 7.22 | 60.0 | 1 |
| Blood CHEMBL613416 | IC50 | 5.3 | 5.3 | 5000.0 | 1 |
| Tyrosine-protein kinase Lck CHEMBL258 | IC50 | 5.22 | 5.22 | 6000.0 | 1 |
| Macrophage colony-stimulating factor 1 receptor CHEMBL1844 | IC50 | 5.16 | 5.16 | 7000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mitogen-activated protein kinase 14 | Ki | = | 0.8 | nM | 9.1 | Displacement of fluorescent ATP competitive ligand from p38alpha | 18789685 |
| Dual specificity mitogen-activated protein kinase kinase 1 | IC50 | = | 30.0 | nM | 7.52 | Inhibition of MEK1 by cRaf/mek/Erk cascade assay | 18789685 |
| PBMC | IC50 | = | 60.0 | nM | 7.22 | Inhibition of LPS-stimulated TNFalpha release in human PBMCs | 18789685 |
| Blood | IC50 | = | 5000.0 | nM | 5.3 | Inhibition of LPS-stimulated TNFalpha release in human whole blood | 18789685 |
| Tyrosine-protein kinase Lck | IC50 | = | 6000.0 | nM | 5.22 | Inhibition of LCK | 18789685 |
| Macrophage colony-stimulating factor 1 receptor | IC50 | = | 7000.0 | nM | 5.16 | Inhibition of cFMS | 18789685 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18789685 | 10.1016/j.bmcl.2008.08.051 | Mitogen-activated protein kinase 14 | 1 |
| 18789685 | 10.1016/j.bmcl.2008.08.051 | Dual specificity mitogen-activated protein kinase kinase 1 | 1 |
| 18789685 | 10.1016/j.bmcl.2008.08.051 | Cyclin-dependent kinase 2 | 1 |
| 18789685 | 10.1016/j.bmcl.2008.08.051 | Macrophage colony-stimulating factor 1 receptor | 1 |
| 18789685 | 10.1016/j.bmcl.2008.08.051 | Epidermal growth factor receptor | 1 |
| 18789685 | 10.1016/j.bmcl.2008.08.051 | Receptor tyrosine-protein kinase erbB-4 | 1 |
| 18789685 | 10.1016/j.bmcl.2008.08.051 | Mitogen-activated protein kinase 10 | 1 |
| 18789685 | 10.1016/j.bmcl.2008.08.051 | Tyrosine-protein kinase Lck | 1 |
| 18789685 | 10.1016/j.bmcl.2008.08.051 | Serine/threonine-protein kinase PLK1 | 1 |
| 18789685 | 10.1016/j.bmcl.2008.08.051 | Serine/threonine-protein kinase Sgk1 | 1 |
| 18789685 | 10.1016/j.bmcl.2008.08.051 | Vascular endothelial growth factor receptor 2 | 1 |
| 18789685 | 10.1016/j.bmcl.2008.08.051 | PBMC | 1 |
| 18789685 | 10.1016/j.bmcl.2008.08.051 | Blood | 1 |
Data from ChEMBL 36 via Core Engine