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Assay Detail

CHEMBL997720

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of fluorescent ATP competitive ligand from p38alpha
ChEMBL ↗
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Mitogen-activated protein kinase 14 (CHEMBL260) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Kinase array design, back to front: biaryl amides.
Baldwin I, Bamborough P, Haslam CG, Hunjan SS, Longstaff T, Mooney CJ, Patel S, Quinn J, Somers DO.
Bioorg Med Chem Lett (2008) 18 : 5285 -5289
PubMed 18789685 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 47 7.58 9.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL485286 — — 1 9.10
CHEMBL521722 — — 1 8.96
CHEMBL485285 — — 1 8.85
CHEMBL495729 — — 1 8.77
CHEMBL498390 — — 1 8.62
CHEMBL523559 — — 1 8.55
CHEMBL525727 — — 1 8.54
CHEMBL497563 — — 1 8.40
CHEMBL497375 — — 1 8.35
CHEMBL496312 — — 1 8.33
CHEMBL521734 — — 1 8.22
CHEMBL526452 — — 1 8.17
CHEMBL521548 — — 1 8.17
CHEMBL496528 — — 1 8.17
CHEMBL522579 — — 1 8.00
CHEMBL526639 — — 1 7.96
CHEMBL496943 — — 1 7.96
CHEMBL497352 — — 1 7.92
CHEMBL1964268 — — 1 7.85
CHEMBL496334 — — 1 7.77
CHEMBL497976 — — 1 7.75
CHEMBL498183 — — 1 7.75
CHEMBL497977 — — 1 7.72
CHEMBL526078 — — 1 7.72
CHEMBL525916 — — 1 7.70
CHEMBL495917 — — 1 7.31
CHEMBL496313 — — 1 7.31
CHEMBL495902 GW820759X — 1 7.06
CHEMBL496130 — — 1 7.01
CHEMBL498369 — — 1 6.96

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL485286 — Ki = 0.8 nM 9.10
CHEMBL521722 — Ki = 1.1 nM 8.96
CHEMBL485285 — Ki = 1.4 nM 8.85
CHEMBL495729 — Ki = 1.7 nM 8.77
CHEMBL498390 — Ki = 2.4 nM 8.62
CHEMBL523559 — Ki = 2.8 nM 8.55
CHEMBL525727 — Ki = 2.9 nM 8.54
CHEMBL497563 — Ki = 4.0 nM 8.40
CHEMBL497375 — Ki = 4.5 nM 8.35
CHEMBL496312 — Ki = 4.7 nM 8.33
CHEMBL521734 — Ki = 6.0 nM 8.22
CHEMBL521548 — Ki = 6.8 nM 8.17
CHEMBL496528 — Ki = 6.7 nM 8.17
CHEMBL526452 — Ki = 6.7 nM 8.17
CHEMBL522579 — Ki = 10.0 nM 8.00
CHEMBL526639 — Ki = 11.0 nM 7.96
CHEMBL496943 — Ki = 11.0 nM 7.96
CHEMBL497352 — Ki = 12.0 nM 7.92
CHEMBL1964268 — Ki = 14.0 nM 7.85
CHEMBL496334 — Ki = 17.0 nM 7.77
CHEMBL497976 — Ki = 18.0 nM 7.75
CHEMBL498183 — Ki = 18.0 nM 7.75
CHEMBL526078 — Ki = 19.0 nM 7.72
CHEMBL497977 — Ki = 19.0 nM 7.72
CHEMBL525916 — Ki = 20.0 nM 7.70
CHEMBL495917 — Ki = 49.0 nM 7.31
CHEMBL496313 — Ki = 49.0 nM 7.31
CHEMBL495902 GW820759X Ki = 87.0 nM 7.06
CHEMBL496130 — Ki = 98.0 nM 7.01
CHEMBL498369 — Ki = 110.0 nM 6.96
CHEMBL496104 — Ki = 110.0 nM 6.96
CHEMBL498386 — Ki = 130.0 nM 6.89
CHEMBL522893 — Ki = 160.0 nM 6.80
CHEMBL496736 — Ki = 290.0 nM 6.54
CHEMBL495901 — Ki = 380.0 nM 6.42
CHEMBL497987 — Ki = 420.0 nM 6.38
CHEMBL496338 — Ki = 490.0 nM 6.31
CHEMBL521887 — Ki = 830.0 nM 6.08
CHEMBL526101 — Ki = 1100.0 nM 5.96
CHEMBL497350 — Ki = 1400.0 nM 5.85
CHEMBL501431 — Ki = 2000.0 nM 5.70
CHEMBL496339 — Ki > 2500.0 nM -
CHEMBL498391 — Ki > 2500.0 nM -
CHEMBL497986 — Ki > 2500.0 nM -
CHEMBL497353 — Ki > 850.0 nM -
CHEMBL496756 — Ki > 850.0 nM -
CHEMBL496129 — Ki > 850.0 nM -