Assay Detail
Functional
CHEMBL997716
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LPS-stimulated TNFalpha release in human whole blood
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Kinase array design, back to front: biaryl amides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.04 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL526639 | — | — | 1 | 7.00 |
| CHEMBL521734 | — | — | 1 | 6.30 |
| CHEMBL495729 | — | — | 1 | 6.16 |
| CHEMBL478649 | — | — | 1 | 6.00 |
| CHEMBL522579 | — | — | 1 | 6.00 |
| CHEMBL497563 | — | — | 1 | 5.52 |
| CHEMBL485286 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL526639 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL521734 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL495729 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL478649 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL522579 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL497563 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL485286 | — | IC50 | = | 5000.0 | nM | 5.30 |