Assay Detail
Binding
CHEMBL998642
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Inhibition of POP in Sprague-Dawley rat brain homogenates
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Prolyl oligopeptidase inhibition by N-acyl-pro-pyrrolidine-type molecules.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.94 | 9.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL458975 | — | — | 1 | 9.09 |
| CHEMBL459149 | — | — | 1 | 9.06 |
| CHEMBL515056 | — | — | 1 | 8.52 |
| CHEMBL45594 | — | — | 1 | 7.96 |
| CHEMBL289651 | — | — | 1 | 7.52 |
| CHEMBL458976 | — | — | 1 | 7.40 |
| CHEMBL516159 | — | — | 1 | 7.39 |
| CHEMBL298028 | — | — | 1 | 7.32 |
| CHEMBL457904 | — | — | 1 | 7.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL458975 | — | IC50 | = | 0.81 | nM | 9.09 |
| CHEMBL459149 | — | IC50 | = | 0.88 | nM | 9.06 |
| CHEMBL515056 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL45594 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL289651 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL458976 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL516159 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL298028 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL457904 | — | IC50 | = | 59.0 | nM | 7.23 |